Granted this is somewhat narrower than my title suggests, but it should make you think twice about eating sucralose (Splenda).
Diabetes Care | Mobile
OBJECTIVE Nonnutritive sweeteners (NNS), such as sucralose, have been reported to have metabolic effects in animal models. However, the relevance of these findings to human subjects is not clear. We evaluated the acute effects of sucralose ingestion on the metabolic response to an oral glucose load in obese subjects.